Cordyceps sinensis biomass produced by submerged fermentation in high-fat diet feed rats normalizes the blood lipid and the low testosterone induced by diet

نویسندگان

  • Leandro Freire dos Santos
  • Rosália Rubel
  • Sandro José Ribeiro Bonatto
  • Ana Lucia Zanatta
  • Júlia Aikawa
  • Adriana Aya Yamaguchi
  • Maria Fernanda Torres
  • Vanete Thomaz Soccol
  • Sascha Habu
  • Karin Braun Prado
  • Carlos Ricardo Soccol
چکیده

This study investigated the effect of Cordyceps sinensis biomass supplementation obtained from submerged fermentation on blood lipid and low testosterone induced by high-fat diet (HFD). The experiments were carried out using a long-term intake of HFD and HFD plus Simvastatin or C. sinensis (4 months). Our results show that plasma cholesterol, triglycerides and LDL were decreased by Cordyceps sinensis biomass supplementation (CSBS). A long-term intake of HFD caused a significant liver damage which has been reverted by CSBS. CSBS normalized decreasing testosterone levels observed in high-fat diet feed rats. All these findings lead us to suggest that C. sinensis was able to decrease blood lipid concentration, increase hepatoprotective activity and normalize testosterone levels.

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2012